Tyrosinase: 59.8% ± 1.3% (330 μg/mL). ORAI1 Inh: 80.30% ± 2.22% (100 μg/mL). ET-1 Inh: 69.96% ± 0.38%.Therapeutic potential for the treatment of melasma or the prevention of direct and indirect UV-induced melanogenesis. The gene discussed is TYR; the disease is freckles.