VEGFA and preeclampsia: Furthermore, as a consequence of this rise in free radical generation, an increase in anti-angiogenic soluble FMS-like tyrosine kinase-1 (sFlt-1) has been observed, neutralizing circulating endothelial growth factor (VEGF) and impairing the formation of new placental vessels and the placenta function, facts which are associated with preeclampsia and intrauterine growth restriction [41,42,43].