TNF and cancer: Individually, EGCG [34] and curcumin [28] have been shown to counteract tumor growth and ameliorate cancer cachexia in vivo, but their combination failed to improve skeletal muscle atrophy and survival in the C-26 mouse model of cancer cachexia, likely due to the failure to reduce plasma TNF-α levels, systematic oxidative stress and ubiquitin-proteasome system activation [158].