GRM1 and paraneoplastic cerebellar degeneration: While the presence of paraneoplastic mGluR1-autoantibodies likely has a pathophysiological effect on the function of these receptors, an autopsy study of a patient with mGluR1-positive Hodgkin-related paraneoplastic cerebellar degeneration [32] showed decreased density of Purkinje cells, most pronounced in the flocculus, nodulus and anterior lobes.