AKT1 and brain ischemia: Conversely, another report showed that antagomiR-124 administered 24 h before cerebral ischemia–reperfusion injury produces a neuroprotective effect by promoting the PI3K/Akt/mTOR pathway, with rats exhibiting an increase in the PI3K/Akt/mTOR levels and improvement in neurological function, in part, due to downregulation of autophagy by the PI3K/Akt/mTOR pathway [132].