ALB and immune system disorder: Other clues that favor the diagnosis of AOA2 in comparison to the other differentials include no ocular telangiectasis or immunodeficiency (to exclude AT and ATLD), teenage onset (AOA1, AOA4, and AT typically have an onset < 10 years), normal albumin (more commonly decreased in AOA1), and cholesterol levels (more commonly increased in AOA1) [13,16,17].