Furthermore, a network-based meta-analysis of four blood microarray studies has demonstrated that the Polypyrimidine Tract Binding Protein 1 (PTBP1) gene, encoding a protein highly implicated in the mRNA translation and stabilization of insulin and previously related to diabetes, was the most significantly downregulated gene of PD patients compared to controls [97]. The gene discussed is PTBP1; the disease is diabetes mellitus.