SNCA and Parkinson disease: Furthermore, sirtuin 2 (SIRT2), a HDAC, is highly implicated in the core pathophysiological mechanisms of PD, such as α-synuclein aggregation, autophagy, oxidative stress, and neuroinflammation, although with conflicting results; there is evidence on the neuroprotective but also detrimental role of SIRT2 in dopaminergic degeneration [29].