SIRT1 and Hyperglycemia: Interestingly, phoenixin was previously shown to exert anti-inflammatory neuroprotective effects which relied on SIRT-1 [32], a protein also involved in the function of the DMN in energy homeostasis [42], regulating glucose by reducing diet-induced hyperglycemia [44] and increasing peripheral insulin sensitivity [45] while also playing a role in maintaining body weight [46].