PN was able to alter the binding of important transcription factors in prostate cancer including C/EBP-alpha, fos-related antigen-1 (FRA-1), HOXA-4, c-MYB, SNAIL, SP1, serum response factor (SRF), STAT3, X-box binding protein-1 (XBP1), and p53 [88]. This evidence concerns the gene FOSL1 and Familial prostate cancer.