While in the CANTOS study the relevant role is for IL-6 and IL-1B in patients with ischemic heart disease [20], Gardner et al. demonstrated that in patients with PAD, TNF-α and IL-8 levels were increased but not IL-6 levels [22], which supports the fact that both diseases seem to show differences in the inflammatory pattern. The gene discussed is IL1B; the disease is coronary artery disorder.