Furthermore, USP15 deubiquitinates and stabilizes kelch like ECH associated protein 1 (KEAP1) to degradate nuclear factor erythroid 2-related factor 2 (NRF2), which is enhanced by xanthine oxidoreductase, thereby leading to the accumulation of reactive oxygen species and changes in the oxidative environment, ultimately inducing cell apoptosis and suppressing the propagation of hepatocellular carcinoma [79]. This evidence concerns the gene NFE2L2 and hepatocellular carcinoma.