USP15 and hepatocellular carcinoma: Although USP15 does not interact with the hepatitis C virus (HCV) proteins and does not participate in innate immune responses, knockout of USP15 inhibits the translation of HCV RNA and the accumulation of lipid droplets in the hepatocellular carcinoma cell line Huh7, as well as the addition of palmitic acids, which partially recovers the production of infectious viral particles, suggesting that USP15 regulates HCV propagation by affecting viral RNA translation and lipid metabolism [118].