USP15 and cancer: However, there has been another report stating that USP15 deubiquitinates IκBα to inhibit the NF-κB pathway, thereby blocking the proliferation and invasion of the gastric cancer cells lines SGC7901 and MKN45 [74].These data indicate that the functions of USP15 are complicated, and functions in the same types of cancer may be different, so continuous exploration is needed.