USP15 stabilizes MDM2 by the deubiquitination and regulation of p53 function, which, in turn, negatively regulates T-cell activation by targeting the degradation of the transcription factor, the nuclearfactorofactivatedT-cells2 (NFATc2), ultimately regulating both tumor growth and anti-tumor immunity [76]. This evidence concerns the gene NFATC2 and neoplasm.