USP15 and familial pancreatic carcinoma: However, the USP15 gene is deleted in 25.37% of pancreatic cancers and 10.9% of glioblastomas, implying a potential tumor suppressive function of USP15 in these cancers [69].USP15 is involved in various cellular processes, such as cell proliferation, cell invasion, apoptosis, autophagy, the cell cycle, genome integrity, transcription regulation, the immune response, and others.