USP15 deubiquitinates and stabilizes caspase-6 to increase cell apoptosis in the chronic myeloid leukemia cell K562, and miR-202-5p inhibits the expression of USP15 by directly targeting the 3’ untranslated region (3’UTR) of USP15 to suppress cell apoptosis [91]. Here, USP15 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.