In addition, the E6 protein can block the deubiquitination of the tripartitemotifcontaining25 (TRIM25) by USP15, which ultimately leads to the degradation of TRIM25, thereby inhibiting the retinoic acid-inducible gene 1 (RIG1)-mediated antiviral signal transduction in the cervical cancer cell line C33A [112,113]. The gene discussed is PLAAT4; the disease is cervical carcinoma.