CCND1 and cancer: In such a way, we hypothesized that cyclin D1 CCND1, a critical positive regulator of the cell cycle that was extensively implicated in the pathogenesis and tissue-based diagnostics of PTC (reviewed in [145]) but was also described as a target of TAA-AAbs in other cancers [146,147], may also trigger the diagnostically relevant autoantibody response in thyroid tumors.