Using this pipeline, we were able to expand the list of the autoantibody response-eliciting TAAs in follicular cell-derived thyroid tumors by four proteins, namely, glycolytic enzymes pyruvate kinase PKM2 [27,28,29,30,31,32] (see Section 3.1) and phosphoglycerate kinase PGK1, a thin filament-associated protein calponin-3 CNN3, and the tricarboxylic cycle enzyme fumarate hydratase FH. The gene discussed is CNN3; the disease is thyroid tumor.