Additionally, the frequency of TAA-AAbs recognizing clones corresponding to PHD finger protein 20 PHF20, also known as Glioma-Expressed Antigen 2 GLEA2 [118,119], was also significantly higher in thyroid cancer patients than in healthy controls, although these clones also demonstrated rare positive reactions in the latter group and in patients with benign thyroid lesions. This evidence concerns the gene PHF20 and central nervous system cancer.