For example, circulating TAA-AAbs against p53 (p53-AAbs) may be detected long (up to 11 years) before the development of liver angiosarcoma associated with the chronic occupational exposure to vinyl chloride [24]; similarly, p53-AAbs were detected 17–47 months prior to the clinical manifestation of lung cancer in uranium workers [25]. The gene discussed is TP53; the disease is lung cancer.