TLR9 and melanoma: As a result, intracellular mtDNA released into the cytosol can be associated with cGAS–STING, TLR9 (Toll Like Receptor 9), and the inflammasomes NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3), NLRC4 (NLR Family Pyrin Domain Containing 4), and (absent in melanoma 2), which promotes an enhanced immune response [138].