Multiple regression analysis showed that CERT-R1 (Std coeff 0.17, T-value 1.9, p ≤ 0.05) and CERT-R2 (0.21, 2.6, p < 0.05, respectively) remained as independent determinants for WMSI after multivariate adjustment (parameters included in the univariate analysis were: age, gender, diabetes, hypertension, dyslipidemia, BMI, creatinine, fibrinogen, monocytes, platelets, lymphocytes, neutrophils, ESR, NLR, CRP, troponin I-at admission, and ceramides and their ratio) (Table 3). The gene discussed is CRP; the disease is diabetes mellitus.