Similarly, increased anxiogenic-like behaviors and cognitive impairments were detected in the Scn1a +/− mouse model of Dravet syndrome [66], as well as in chemical models of limbic seizures induced by chronic and sub-chronic pentylenetetrazole (PTZ) administration [67,68]. The gene discussed is SCN1A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.