AGP is known to suppress the overexpression of pro-inflammatory cytokines in the tumor microenvironment, including (TNF-α) and interleukins (IL-6), in which it is linked to drug resistance and metastasis [25,26,27], while HA is a naturally occurring ligand with a high binding affinity for the cluster of differentiation-44 (CD44) receptors [28]. This evidence concerns the gene CD44 and neoplasm.