Moreover, depleted levels of Lactobacillus in CRC rats could be involved in the oxidative status of the animals since this genus was shown to be protective and significantly improve antioxidant status in colonic tissue from rats with ulcerative colitis [60], evidenced by the increased activity of the antioxidant enzymes CAT and SOD, which were altered in CRC groups. Here, SOD1 is linked to ulcerative colitis.