Apart from the role of VIP and PACAP receptors in physiological processes, they are also known to be involved in the progression of malignancies and tumor growth stimulation along with angiogenesis because of transactivation of epidermal growth factor receptor (EGFR) and the expression of vascular endothelial growth factor (VEGF) [30,31]. The gene discussed is EGFR; the disease is neoplasm.