Mathios et al. (2015) [300] observed that the administration of the IL-15 superagonist complex ALT-803 in a murine model led to greater animal survival and durable antitumor response, but the simultaneous depletion of TCD4+ and TCD8+ cells abrogated the benefit in survival, whereas the depletion of NK cells alone did not affect the survival, suggesting that in spite of the presence of NK cells being detected infiltrating the tumor, their actions might not be crucial to the effect of this therapy in GBM. Here, IL15 is linked to glioblastoma.