Another confounding factor in these patients is that that GATA2 and MCM4—the two main genes involved in the origin of CNKD—could be relevant in carcinogenesis [97,98], including GATA2 mutations identified in families with predisposition to myelodysplastic syndrome and acute myeloid leukemia (MDS-AML) [97]. Here, MCM4 is linked to myelodysplastic syndrome.