CSF2 and neoplasm: Another promising cytokine for cancer immunotherapy is IL-12, which presents several effects, being able to stimulate the production of cytokines by NK cells—such as IFN-γ, GM-CSF, and TNF-α [269]—to augment the cytolytic capacity of NK cells and TCD8+ lymphocytes, to promote the polarization of the TCD4+ lymphocytes to a Th1 profile [303], and to increase the ADCC against tumor cells opsonized with antibodies [304].