In glioblastoma, IL-15 can have effects in different types of therapy [296,297,298], and regarding its effects in NK cells, Ma et al. (2021) [299] saw that the in vitro administration of a herpes-simplex-1-based oncolytic virus (OV) expressing the human IL-15/IL-15Rα sushi domain fusion protein (named OV-IL15C) was able to promote the secretion of soluble IL-15/IL-15Rα complexes by the infected GBM cells, inducing tumor cytotoxicity and greater survival of NK and TCD8+ cells. The gene discussed is IL15; the disease is glioblastoma.