DNAM-1 is well established as a co-activating receptor, and has important functions in tumor immunosurveillance, given that its absence in knockout mice favors the incidence and growth of carcinogen-induced tumors, as well as reducing the clearance of CD155+ transplanted tumor cells in vivo and the cytotoxic activity of NK and T cells in vitro [59]. Here, CD226 is linked to neoplasm.