Another phenotypic change described in NK cells in GBM patients was the lower expression of the chemokine receptor CXCR3 in peripheral blood NK cells compared to tumor NK cells [132]; this could impair the infiltration in the tumor microenvironment, considering that CXCR3 expression in NK cells has been shown to be crucial for this process in other tumor models in mice [138]. The gene discussed is CXCR3; the disease is glioblastoma.