For instance, lipopolysaccharides (LPSs) are reportedly involved in the carcinogenesis of colorectal cancer through the activation of nuclear factor kappa B (NF-κB) and β-catenin via Toll-like receptor (TLR) 4 in the gut, which is predominantly colonized by gram-negative bacilli [6,7]. This evidence concerns the gene NFKB1 and colorectal cancer.