LDHA and cancer: ALDH is a cancer stemness marker, which is also shown to promote metastasis and treatment resistance [58], herein, we showed that compared to control or vehicle-treated cells, SSZ (50 μM, 48 h) suppressed ALDH activity in the DLD-1 cells by 11.64%, while in the HCT116 cells, it displayed a 5.5% reduction (Figure 11C).