A boxplot of non-responder and responder values, as indicated by the box plot center line, evidently shows that expressions of the KRAS/MMP7/CD44 genes in the colorectal adenocarcinoma (COAD) cohort from the ROC analysis revealed that these genes influenced the response of treatment by lowering the response rate of treatment in CRC patients. This evidence concerns the gene KRAS and colorectal adenocarcinoma.