ATXN3 and Spinocerebellar ataxia type 3: Using a drug repurposing approach, we previously identified citalopram, a Selective Serotonin Reuptake Inhibitor (SSRI), as a hit compound capable of reducing the proteotoxicity of mutant ATXN3 in Caenorhabditis elegans (C. elegans) and mice [8,9], suggesting that the modulation of the serotoninergic system exerts a positive role in MJD.