The pleiotropic locus MTNR1B (lead SNP rs4237555) was identified among type 2 diabetes (z score, −7.86; P = 3.84 × 10−15), FG (z score, −19.19; P = 4.20 × 10−82), HbA1c (z score, −7.50; P = 6.26 × 10−14), and chronotype (z score, −4.85; P = 1.22 × 10−6). The gene discussed is MTNR1B; the disease is type 2 diabetes mellitus.