That no major change in vascular smooth muscle cell layer was observed was further supported by the quantitative proteome analyses of the aneurysm wall showing no change in proteins associated with vascular smooth muscle cells contractile phenotype [35]; myosin 11, α-actin, transgelin/SM22, calponin-1, myosin regulatory light polypeptide 9, and topomyosin β chain (Supplementary Table S2 and Supplementary Figure S2, yellow dots) between vehicle and CAG-treated rats. Here, TAGLN is linked to aneurysm.