The levels of C-reactive protein, procalcitonin, lactate, sPLA2GIIA, presepsin, sIL2Rα, sTREM-1, and MR-proADM were measured at ED admission in 773 patients with definitive diagnosis of sepsis; at the end of microbiological work-up, 449 and 324 of the septic patients were deemed to be CnS and CpS, respectively. Here, CRP is linked to Sepsis.