CDH1 and neoplasm: Due to the dense-diffuse and vesicular expression pattern of E-cadherin already described in high-magnification images (Figure 2 and Figure 3), LAMP1 and Giantin vesicles showed a high degree of overlapping with E-cadherin (0.756 ± 0.069% and 0.797 ± 0.087%, respectively) (Figure 8A) in tumor tissue.