We first tested whether the MD901 DLBCL cell line was sensitive or not to R406, an ATP competitive inhibitor of the spleen tyrosine kinase (SYK) that only induces apoptosis in DLBCL cell lines having an active BCR signaling, whereas OxPhos-DLBCLs that do not display functional BCR signaling are insensitive to this inhibitor [16]. Here, BCR is linked to diffuse large B-cell lymphoma.