Since RelB-dependent metabolic pathway in MD901 DLBCL cells involves stimulation of OxPhos (Figure 2c,d), and RelB impacts on DLBCL survival upon the treatment with antimetabolic drugs (Figure 3a–c), we next examined whether RelB activation in DLBCL cells upregulates the expression of endogenous NF-κB responsive genes involved in oxidative/metabolic stress response and survival upon combination of these two antimetabolic drugs. Here, NFKB1 is linked to diffuse large B-cell lymphoma.