Taken together, these results indicate that RelB activation in OxPhos-DLBCL cells is associated with increased expression of a subset of NF-κB target genes involved in oxidative stress response (MnSOD), inhibition of metabolic stress-induced cell death (GADD45β) and extrinsic mitochondrial apoptotic pathway of survival (cIAP2) upon antimetabolic treatment. Here, SOD2 is linked to diffuse large B-cell lymphoma.