F2R and osteosarcoma: Similarly, in proteinase-activated receptor 1 (PAR1)-driven tumors, both inhibition and silencing of MALT1 impairs the expression of NF-κB target genes, such as IL1B, CXCL8, and MMP9, each associated with the manifestation of malignant features in breast cancer and osteosarcoma (OS) [83].