In the context of a GPCR-activated C10BM signalosome, a study in ovarian cancer (OC) cells has uncovered a lysophosphatidic acid (LPA) receptor-PKCα-C10BM signaling axis that induces tumor progression via activation of NF-κB and urokinase plasminogen activator (uPA) [85]. This evidence concerns the gene PLAU and neoplasm.