Mutations of CARD11, which can be found in an aggressive subtype of DLBCL, Sézary syndrome, angioimmunoblastic T-cell lymphoma (AITL), and adult T-cell leukemia/lymphoma (ATLL), disrupt the auto-inhibition of CARD11 and drive its receptor-independent oligomerization, thus activating MALT1 [63,64,65,66]. Here, MALT1 is linked to angioimmunoblastic T-cell lymphoma.