PRKDC and glioblastoma: As phase-0 can expedite drug development and potentially saving 2–2.5 years in comparison with traditional approaches, including the benefit of phase-I integration, there is an increasing demand for such trial practices and it has been observed in the analysis of DDR inhibitors: Nedisertib (DNA-PK) and Adavosertib (WEE1) for GBM patients.