Lastly, since SAPs can be co-assembled with diluent SAPs (without a bioactive epitope) as an approach to control the density of biological signals [14] and therefore attain enhanced bioactivity in cases where steric effects play an important role in signaling [15], we investigated the effect of the co-assembly of RADA16 and fAPs (dubbed cAP-Soy1 and cAP-Lup1) for the growth of Caco-2 human intestinal cells and contextually we characterized their biological activities as DPP-IV and ACE inhibitors, in order to demonstrate their potential use for the prevention of metabolic syndrome. Here, ACE is linked to metabolic syndrome.