Elevated BAFF and APRIL are correlated with skin thickening [81,83]. Increased IL-6-producing Beffs increase inflammation, while decreased IL-10-producing Bregs exhibit a reduced capacity for immunosuppression [82]. In SSc peripheral blood, an increase in naïve and a decrease in activated memory B cells is observed compared to healthy controls [4,85,87,91]. This evidence concerns the gene TNFSF13B and systemic sclerosis.