Indeed, an elevated expression of type 1 IFN signaling (IFN-α, IRF5, IRF7, IRF8) and its inducible genes (IL-6, STAT1, STAT3) has been illustrated in tissue biopsies, the peripheral blood, and serum of SSc patients and was correlated with disease severity [55]. This evidence concerns the gene IFNA1 and systemic sclerosis.