ERBB2 and breast cancer: Routine immunohistochemical analysis of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67 expression (proliferation index) is currently used to determine the four basic molecular subtypes of BC: Luminal A-like, luminal B-like, HER2-overexpresing, and triple-negative BCs.