PBK and adenocarcinoma: Two upper gastrointestinal (GI) adenocarcinomas (ESCA and STAD) exhibited superior OS and DFS according to PBK/TOPK expression (ESCA OS HR = 0.71, DFS HR = 0.8; STAD OS HR = 0.82, DFS HR = 0.62); however, they did not reach statistical significance (Figure 1A and Supplementary Figure S4).