MAPT and early-onset autosomal dominant Alzheimer disease: Neurodegenerative diseases with a cerebral accumulation of tau aggregates are called tauopathies and include Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD) such as Pick’s disease (PiD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17) [1,2,3].