A greater example would be the blockade of ERRγ (estrogen related receptor γ), an orphan nuclear receptor [58,59], which modulates fibrinogen levels in hypofibrinogenemia states caused by diet-induced obesity, diabetes mellitus type 2, liver injury and alcohol-induced oxidative stress [60,61]. The gene discussed is ESRRB; the disease is obesity due to melanocortin 4 receptor deficiency.