Since C. elegans does not possess orthologues of ApoE, one of the major modulatory genes in human AD, the models that have been generated in C. elegans to study the effect of different ApoE alleles have been based on coexpression in the neurons of Aβ and the different human ApoE alleles, ApoEε2, ApoEε3 and ApoEε4 [82]. This evidence concerns the gene APOE and Alzheimer disease.