[173] Two meta-analyses of 134 and 535 NAFLD patients from 4 and 9 RCTs, respectively, have confirmed that probiotics can improve insulin sensitivity, ameliorate dyslipidaemia and systemic inflammation, reduce intrahepatic fat content, and rescue impaired liver function, overall improving the clinical outcomes in NAFLD [174,175]. This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.