Simtuzumab (GS-6624), a humanized antagonist mAB, was one of the first LOXL2-targeting drug candidates, that was discontinued after showing a lack of efficacy regarding liver fibrosis and/or portal hypertension in two phase 2b trials in patients with bridging fibrosis or compensated cirrhosis associated with NASH [86]. Here, LOXL2 is linked to Hepatic fibrosis.