Sirtuin 1 (SIRT1), the SIRT1/NF-κB axis, SIRT3, and SIRT4 play a major role in regulating hepatic lipid metabolism, controlling oxidative stress, and mediating chronic inflammation in NAFLD and alcoholic fatty liver disease [253,254,255]. The gene discussed is SIRT1; the disease is metabolic dysfunction-associated steatotic liver disease.