After a promising pilot study demonstrating an attenuation of platelet and immune activation markers after 1 week of low-dose ASA therapy [130], in 2016, O’Brien et al. conducted a double-blind, randomized, placebo-controlled trial on HIV-infected participants on suppressive ART to compare 12 weeks of ASA versus placebo on soluble markers of coagulation (sCD14, IL-6 and D-dimer), serum level of thromboxane-B2 and endothelial dysfunction. This evidence concerns the gene IL6 and endothelial dysfunction.