About 70% of G × G and G × E interaction models associated with the level of total blood cholesterol in CAD patients comprised interactions between eight loci such as GALNT2, LPA, SCARB1, APOC1, LILRA3, ST3GAL4, COBLL1, and PSKH1 and certain literature data confirms the roles of these genes in the regulation of cholesterol metabolism. Here, COBLL1 is linked to coronary artery disorder.