Interestingly, expression of the BHLHE23 gene can be suppressed by environmental chemicals, including those found in the tobacco smoke [94], polycyclic aromatic hydrocarbons [95], biphenol A [96], acrylamide [97], dietary fats [98], and many of them are well known risk factors for atherosclerosis [99]. The gene discussed is BHLHE23; the disease is atherosclerosis.