As can be seen from the interactome network of CIMT (Figure 1), three independent “chains” of interacting genes such as F2 × NPC1L1 × PPP1R3B × CETP × LILRA3, F2 × PLTP × ST3GAL4 × LILRA3 and F2 × SCARB1 × ZNF648 × GALNT2 × LPA × LILRA3 were associated with carotid intima-media thickness in CAD patients. The gene discussed is ZNF648; the disease is coronary artery disorder.