Interactions between thirteen loci such as ABCA1, APOC1, CETP, F2, GALNT2, LILRA3, LPA, NPC1L1, PLTP, ST3GAL4, ZNF648, SCARB1, and PPP1R3B contributed to carotid intima-media thickness in patients with coronary artery disease. The gene discussed is NPC1L1; the disease is coronary artery disorder.