What is becoming apparent is the interconnectedness between many of these biomarkers, as evidenced by CHI3L1-mediated suppression of E-cadherin expression [139], microbiota-derived metabolite involvement in epigenetic alteration [140], and the effect of miRNA in the growth and composition of the gut microbiota [141], which may contribute to the reported role of miRNA-associated colon carcinogenesis [110]. This evidence concerns the gene CDH1 and digestive system cancer.