CHI3L1 and colorectal carcinoma: A finding of high levels of CHI3L1 in colonic biopsies from patients with IBD [46] and CRC [47] links CHI3L1 with inflammation, and this is confirmed by increased Interleukin (IL)-8 secretion in vitro when intestinal epithelial cells are engineered to overexpress CHI3L1 [47].