KLF2 and atherosclerosis: In the early stages of atherosclerosis, Montelukast was shown to promote KLF2 expression in an ERK5-mediated way, which resulted in a reduction of oxLDL-induced monocyte adhesion to HUVECs and suppression of adhesion molecule genes expression (VCAM-1 and E-selectin), thus, confirming athero-protective properties [56].