GSK3B and atypical Rett syndrome: Another study reinforces Gsk3β-mediated neuroinflammation, partially by enhancing nuclear factor kappa b subunit 1 (Nfkb1) signaling, where the inhibition of Gsk3β with the SB216763 inhibitor reduces Nfkb1 signaling and inflammation levels, in a mouse model of Rett syndrome [81].