The pathways found to be significantly altered in microglia from CMVMJD135 mice when compared with WT mice were as follows: oxidative stress (Junb and Fos (also known as c-Fos)); TGF-β receptor signaling pathway (Fos, Junb, and Mef2c); TNF-α NF-kβ signaling pathway (Gsk3β, Usp11, and Alpl); role of NFAT in regulation of the immune response (Fos, Gsk3β, and Mef2c); the novel Jun-Dmp1 pathway (Junb and Fos); FAT10 cancer signaling pathway (Bmpr2 and Gsk3β); ERK5 signaling (Fos and Mef2c); Wnt/β-catenin signaling (Bmpr2, Gsk3β, and Sox8); and delta-notch signaling pathway (Gsk3β and Mef2c). The gene discussed is SOX8; the disease is cancer.