In fact, regarding the specific MJD DEGs here identified and known to be involved in the lipid metabolism, Acsl4 was found to be a novel regulator of neuroinflammation in ischemic stroke, and the knockdown of Acsl4 expression was proposed to provide a potential therapeutic target through the inhibition of pro-inflammatory cytokine production in microglia [95]. This evidence concerns the gene ACSL4 and ischemic stroke.