In order to further verify that SLC27A5 regulates the progression of HCC, we established HepG2-shSLC27A5 cell lines and found that knockdown SLC27A5 suppressed the expression of tyrosine-metabolizing enzymes (TAT, HPD, HGD, GSTZ1, and FAH) (Figure 5A). The gene discussed is TAT; the disease is hepatocellular carcinoma.