Despite this, the antitumor protection of RHuT vaccination against the onset of TUBO carcinoma was complete in perforin- and complement-deficient mice, other than in BALB/c mice, suggesting that the ADCC, CDC, and CDCC effector mechanisms play only a marginal, if any, role, in this transplantable model of mammary cancer. This evidence concerns the gene PRF1 and breast cancer.