To shed light on the role of ADCC, CDC, and CDCC in the anti-tumor protection elicited by anti-Her2 vaccination, here we exploited a DNA vaccine (RHuT), highly effective in inducing anti-Her2 antibodies [19,20,21] in neuT mice, which are a preclinical model of Her2+ breast cancer [22], developing invasive and metastasizing [23] Her2+ breast tumors in each mammary gland [24,25]. Here, ERBB2 is linked to neoplasm.