In contrast, HF macrophages showed also a selective reduction of pro-hypertrophic signaling markers such as Map3k2 (mitogen activated protein kinase kinase kinase 2, MEKK2) [27] and Sik1 (salt inducible kinase 1) [28], as well as Map3k5 (mitogen activated protein kinase kinase kinase 5, ASK1), a reported determinant factor in Angiotensin 2- and aldosterone/salt-induced cardiac hypertrophy [25,29]. Here, MAP4K5 is linked to hydrops fetalis.