However, HF macrophages also displayed a decrease in several M1-like markers (Figure 5) among which Irak2 (Interleukin 1 receptor associated kinase like 2), Il17ra, Sik1 (cited above in hypertrophic markers), and Map3k2 (MEKK2) [59] (Figure 4). Here, SIK1 is linked to hydrops fetalis.