HF macrophages, isolated from hypertrophic hearts with altered function, displayed a downregulation of several anti-hypertrophic factors such as Myl2 and Myl3 (myosin regulatory light chain 2 and 3), Adam22 (disintegrin and metalloproteinase domain-containing protein 22) and Tet2 (methylcytosine dioxygenase) [23,24,25,26]. Here, ADAM22 is linked to hydrops fetalis.