PKM and hydrops fetalis: In contrast, several genes associated with glycolysis were progressively upregulated in response to Iso or increased in ECH macrophages and maintained elevated in HF macrophages (Figure 5), among which Ldha (lactate deshydrogenase), Pgk1 (phosphoglycerate kinase 1), Pkm (pyruvate kinase muscle isoform), Tpi1 (Triose phosphate isomerase 1), and Gapdh (glyceraldehyde-3 phosphate deshydrogenase).