Beyond that, a number of new findings revealed that KSM possesses several unexpected biological activities effectively countering some recalcitrant human diseases: (i) an in vitro and in vivo study showed that the combination of KSM with rifamycin is in a position to control Mycobacterium tuberculosis, [5] (ii) KSM was recently shown to be capable of inhibiting herpes simplex virus-2 (HSV-2), [6] and (iii) KSM has also been shown to have a promising activity against COVID-19 by inhibiting 3a-channel [7] and chitinase 3-like-1 (CHI3L1) proteins [8]. Here, CHI3L1 is linked to COVID-19.