CD8A and central nervous system cancer: Similarly, Weenink et al. quantified the TILs in both lower and high-grade glioma (LGG and HGG) samples and discovered that LGG contained fewer CD8+ T cells, which was related to the lower expression of CXCL9, CXCL10, and ICAM1, the relative absence of TILs in LGG was thought to potentially affect the therapeutic efficacy of immune checkpoint inhibitors in this context [117].