MKI67 and neoplasm: Our data also showed that 5-day treatment of tumor-bearing mice with 5 mg/kg/day of Pd2Spm or 2 mg/kg/day of cisplatin results in comparable anticancer effects when (i) tumor volume reduction, (ii) tumor proliferative activity decrease (Ki-67 and mitotic count) and (iii) tumor DNA damage increase are compared in Pd2Spm- versus cisplatin-treated animals.