When exploring the data from the individual mice, we found that the long-term hyperglycemia, calculated as the AUC of the glucose curves during the 8-week study (data shown in Figure 1C), negatively correlated to the percentage of insulin+ cells (Figure 4A) and positively correlated with the percentage of glucagon+ cells (Figure 4B). The gene discussed is INS; the disease is Hyperglycemia.