Moreover, most currently used DNA assays fail to detect epigenetic modifications (such as promoter hypermethylation), as well as mutations located deep within introns that may alter the mRNA [17].Here, we hypothesized that measuring the level of BRCA1 and BRCA2 mRNA in ovarian cancer tissue may provide additional information when DNA tests are negative or inconclusive. Here, BRCA1 is linked to ovarian cancer.